Given Name

Xiaojun

Family Name

Wang

Current Position

Professor

Organization

Harbin Veterinary Research Institute, CAAS

Nationality-Resident

China

Major Interest

Equine infectious diseases; virus-host interaction;   vaccine; diagnosis technology

Education

Ph.D., Virology, Harbin   Veterinary Research Institute, Chinese   Academy of Agriculture Sciences, Harbin, July 2003.

M. Sc., Microbiology, Harbin Veterinary Research Institute, Chinese   Academy of Agriculture Sciences, Harbin, July 1999.

Bachelor, Veterinary Medicine, Animal Husbandry College, University of Inner Mongolia   for the Nationalities, China, July 1996.   

Post-graduate Training

2005-2010, Visiting Scholar, Department of Microbiology and Molecular   Genetic, Michigan State University, East Lansing, MI, US.

Professional Experience

 1999-2002     Research   Assistant, Harbin Veterinary Research Institute, CAAS, Harbin, China;      Molecular epidemiology and evolution of   equine infectious anaemia virus (EIAV);

2002-2005       Assistant professor, Harbin Veterinary   Research Institute, CAAS, Harbin, China  Pathogenesis   of EIAV

2005-2010       Visiting Scholar, Department of   Microbiology and Molecular Genetic, Michigan State University, East Lansing,   MI, US.     Innate immune restriction   factors; virus-host interaction.

2010-present   Professor, Head of Equine Diseases Study,   Harbin Veterinary Research Institute, CAAS, Harbin, China Innate immunity to virus infection;   Interspecies transmission and adaption of virus; molecular epidemiology and   vaccinology

Honors and Awards

2012      Excellent   Young Scientist, Nature Science Foundation of China

2014      Leading   Talent in Scientific and Technological Innovation，Ministry of Science and   Technology

2016      National   High-level Personnel of Special Support Program

More recent publications

1. Na L, Tang YD, Wang C, Liu C, Wang X*. Rhesus monkey TRIM5alpha SPRY domain contributes to AP-1   activation. J Biol Chem. 2017 Dec 1. pii: jbc.RA117.000127.doi:   10.1074/jbc.RA117.000127. [Epub ahead of print] PubMed PMID: 29196608.

2. Hu Z, Chang H，Chu X，Li S, Wang M, Wang X*, Identification and characterization of a common B-cell   epitope on EIAV capsid proteins, Appl Microbiol  Biotechnol.   2016, Dec;100(24):10531-10542.

3. Ma J, Zhang Z, Yao Q, Su C, Yin X, Wang X*,Regulation of Rev expression by the EIAV tat-rev mRNA   Kozak sequence and its potential influence on viral replication. J   Gen Virol. 2016 Jul 13. doi: 10.1099/jgv.0.000548. [Epub ahead of   print] PubMed PMID: 27411804.

4. Lin YZ, Sun LK, Zhu DT, Hu Z, Wang XF, Du C, Wang YH, Wang X*, Zhou JH*. Equine schlafen 11   restricts the production of equine infectious anemia virus via a codon   usage-dependent mechanism. Virology. 2016 May 17;495:112-121. doi:10.1016/j.virol.2016.04.024. [Epub   ahead of print] PubMed PMID: 27200480.

5. Duan L, Du J, Wang X, Zhou J, Wang X, Liu X. Structural and functional characterization of EIAV   gp45 fusion peptide proximal region and asparagine-rich layer. Virology.   2016Apr; 491:64-72. doi:   10.1016/j.virol.2016.01.010. Epub 2016 Feb 11. PubMed PMID: 26874586.

6. Wang XF, Lin YZ, Li Q, Liu Q, Zhao WW, Du C, Chen J, Wang X*,   Zhou JH*.   Genetic Evolution during the development of an attenuated EIAV vaccine. Retrovirology.   2016 Feb 3;13:9. doi:   10.1186/s12977-016-0240-6. PubMed PMID: 26842878;.

7. Liu Q, Ma J, Wang XF, Xiao F, Li LJ, Zhang JE, Lin YZ,   Du C, He XJ, Wang X*, Zhou   JH*.   Infection with equine infectious anemia virus vaccine strain EIAVDLV121   causes no visible histopathological lesions in target organs in association   with restricted viral replication and unique cytokine response.   Vet Immunol Immunopathol. 2016 Feb;170:30-40. doi:   10.1016/j.vetimm.2016.01.006. Epub 2016 Jan 23. PubMed PMID: 26832985.

8. Zhang Z, Ma J, Zhang X, Su C, Yao QC, Wang X*. Equine   Infectious Anemia Virus Gag Assembly and Export Are Directed by Matrix   Protein through trans-Golgi Networks and Cellular Vesicles. J   Virol. 2015 Dec   4;90(4):1824-38. doi:10.1128/JVI.02814-15. PubMed PMID: 26637458; PubMed   Central PMCID: PMC4734017.

9. Liu, Q.; Wang, XF.; Ma, J.; He, XJ.; Wang, X*.;   Zhou, JH*.   Characterization of Equine Infectious Anemia Virus Integration in the Horse   Genome. Viruses 2015, 7, 3241-3260。 doi:10.3390/v7062769

10. Ma Y, Liu D, Gao J, Wang X*. Similar regulation   of two distinct UL24 promoters by regulatory proteins of equine herpesvirus   type 1 (EHV-1). FEBS Lett. 2015 Jun 4;589(13):1467-75. doi:   10.1016/j.febslet.2015.04.039. Epub 2015 May 1. PubMed PMID: 25937123.

11. Du C, Ma J, Liu Q, Li   YF, He XJ, Lin YZ, Wang XF, Meng QW,   Wang X*, Zhou JH*. Mice   transgenic for equine cyclin T1 and ELR1 are susceptible to equine infectious   anemia virus infection. Retrovirology. 2015 Apr 28;12:36.   doi: 10.1186/s12977-015-0163-7. PubMed PMID: 25928027; PubMed Central PMCID: PMC4422544.

12. Du C,   Liu H, Lin Y, Wang X, Ma J, Li Y, Wang   X*, J. Zhou* Proteomic alteration of equine monocyte-derived macrophages   infected with equine infectious anemia virus Proteomics，2015, online.   DOI: 10.1002/pmic.201400279

13. Tang YD, Na L, Fu LH,   Yang F, Zhu CH, Tang L, Li Q, Wang JY, Li Z, Wang XF, Li CY, Wang X*, Zhou   JH*. Double-stranded RNA-specific   adenosine deaminase 1 (ADAR1) promotes EIAV replication and infectivity. Virology.   2015 Jan 9;476C:364-371. doi: 10.1016/j.virol.2014.12.038. [Epub   ahead of print] PubMed PMID: 25589239.

14. Wang XF, Wang S, Liu Q,   Lin YZ, Du C, Tang YD, Na L, Wang X*,   Zhou JH*. A unique evolution of   the s2 gene of equine infectious anemia virus in hosts correlated with   particular infection statuses. Viruses. 2014 Nov   10;6(11):4265-79. doi: 10.3390/v6114265. PubMed PMID: 25390683.

15. Hu Z, Chang H, Ge M, Lin   Y, Wang X, Guo W, Wang X*.   Development of antigen capture ELISA for the quantification of EIAV p26   protein. Appl Microbiol  Biotechnol.   2014 Nov;98(21):9073-81. doi: 10.1007/s00253-014-6078-8. Epub 2014 Sep   26. PubMed PMID: 25256618.

16. Tang YD, Na L, Zhu CH,   Shen N, Yang F, Fu XQ, Wang YH, Fu LH, Wang JY, Lin YZ, Wang XF, Wang X, Zhou JH, Li CY. Equine   Viperin Restricts Equine Infectious Anemia Virus Replication by Inhibiting   the Production and/or Release of Viral Gag, Env, and Receptor via Distortion   of the Endoplasmic Reticulum. J Virol. 2014 Nov   1;88(21):12296-310. doi: 10.1128/JVI.01379-14. Epub 2014 Aug 13. PubMed PMID:   25122784.

17. Ai Y, Zhu D, Wang C, Su   C, Ma J, Ma J, Wang X*. Core-binding   factor subunit beta is not required for non-primate lentiviral Vif-mediated   APOBEC3 degradation. J Virol. 2014 Oct;88(20):12112-22.   doi: 10.1128/JVI.01924-14. Epub 2014 Aug 13. PubMed PMID: 25122780;

18. Ma J, Wang SS, Lin YZ,   Liu HF, Liu Q, Wei HM, Wang XF, Wang YH, Du C, Kong XG, Zhou JH, Wang X*. Infection of equine   monocyte-derived macrophages with an attenuated equine infectious anemia   virus (EIAV) strain induces a strong resistance to the infection by a   virulent EIAV strain. Vet Res. 2014 Aug 9;45:82. doi:   10.1186/PREACCEPT-1630367192112621. PubMed PMID: 25106750.

19. Hu Z, Zhu C, Chang H,   Guo W, Liu D, Xiang W, Wang X*.   Development of a single-tube duplex EvaGreen real-time PCR for the detection   and identification of EHV-1 and EHV-4. Appl Microbiol Biotechnol. 2014   May;98(9):4179-86. doi: 10.1007/s00253-014-5626-6. Epub 2014 Mar 11. PubMed   PMID: 24615388.

20. Na L, Tang YD, Liu JD,   Yu CQ, Sun LK, Lin YZ, Wang XF, Wang X*,   Zhou JH*. TRIMe7-CypA, an   alternative splicing isoform of TRIMCyp in rhesus macaque negatively   modulates TRIM5α activity. Biochem Biophys Res Commun. 2014   Apr 4;446(2):470-4. doi: 10.1016/j.bbrc.2014.02.132. Epub 2014 Mar 12. PubMed   PMID: 24613845.

21. Wang M, Guo W, Igarashi   I, Xuan X, Wang X, Xiang W, Jia H.   Epidemiological investigation of equine piroplasmosis in China by   enzyme-linked immunosorbent assays. J Vet Med Sci. 2014   Apr;76(4):549-52. Epub 2013 Nov 29. PubMed PMID: 24292247;

22. Yin X, Hu Z, Gu Q, Wu X,   Zheng YH, Wei P, Wang X*. Equine   tetherin blocks retrovirus release and its activity is antagonized by equine   infectious anemia virus envelope protein. J Virol. 2014   Jan;88(2):1259-70. doi: 10.1128/JVI.03148-13. Epub 2013 Nov 13. PubMed PMID:   24227834;

23. Yin X, Lin Y, Cai W, Wei   P, Wang X*. Comprehensive analysis   of the overall codon usage patterns in equine infectious anemia virus. Virol   J. 2013 Dec 20;10:356. doi: 10.1186/1743-422X-10-356. PubMed PMID:   24359511; PubMed Central PMCID: PMC3878193.

24. Hu Z, Wu X, Ge J, Wang X*. Inhibition of virus   replication and induction of human tetherin gene expression by equine IFN-α1.   Vet   Immunol Immunopathol. 2013 Nov 15;156(1-2):107-13. doi:   10.1016/j.vetimm.2013.09.009. Epub 2013 Sep 20. PubMed PMID: 24144682.

25. Wang Q, Ji X, Gao Y, Qi   X, Wang X, Wang Y, Qin L, Gao H,   Wang X*. Overexpression of   microRNA gga-miR-1650 decreases the replication of avian leukosis virus   subgroup J in infected cells. J Gen Virol. 2013 Oct;94(Pt 10):2287-96.   doi: 10.1099/vir.0.054007-0. Epub 2013 Aug 1. PubMed PMID: 23907393.

26. Lu G, Guo W, Qi T, Ma J,   Zhao S, Tian Z, Pan J, Zhu C, Wang X,   Xiang W. Genetic analysis of the PB1-F2 gene of equine influenza virus. Virus   Genes. 2013 Oct;47(2):250-8. doi: 0.1007/s11262-013-0935-x. Epub 2013   Jun 19. PubMed PMID:23780220.